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White Paper Category: Ocular Studies

Subretinal Fibrosis Model in Laser-Induced Choroidal Neovascularization (CNV) Mice

The subretinal fibrosis model in mice is a robust and reliable model to test the efficacy of candidate drugs for pre-clinical studies towards new treatments for anti-leakage (Days 7 and 14), anti-CNV (Days 7 and 14) and anti-fibrosis (Day 35).

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An Experimental Proliferative Vitreoretinopathy (PVR) Model for Testing of New Treatment

The proliferative vitreoretinopathy (PVR) model was successfully induced and demonstrated 28 days after one injection of rabbit conjectunctival fibroblast cells (RCFs). The PVR model is able to test the efficacy of the test articles to discover new treatments for patients with PVR.

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Comparison of Intraocular Pressure Measurements between Tonopen Vet and TonoVet

Both Tonopen Vet and TonoVet tonometers were reliable for measuring IOP in Dutch Belted rabbits without obvious corneal damage.

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Glaucoma Animal Models

Due to incurable, unknown pathogens, glaucoma has been an obstacle in the prevention and treatment of blindness. Novel glaucoma animal models have been developed to find methods of treating the disease.

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Comparison of Endotoxin-Induced Uveitis and Experimental Autoimmune Uveitis Models for Drug Screening

The study is to compare Endotoxin-Induced Uveitis (EIU) Model and Experimental Autoimmune Uveitis (EAU) Model in Lewis Rats in order to benefit how to choose appropriate models for anti-inflammatory drug screening.

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Simplified Methods for Evaluation of A Dry Eye Murine Model Induced by Rimabotulinum Toxin B

The purpose of this study was to evaluate a dry eye murine model using simplified methods for testing the efficacy of potential anti-dry eye compounds as novel dry eye treatments.

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A Modified Chronic Ocular Hypertension Rat Model for Neuroprotective Compound Screening

These results demonstrate that the modified ocular hypertension model is an effective, reliable and accurate model to screen potential neuroprotective compounds.

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A Modified Chronic Ocular Hypertension Rat Model for Retinal Ganglion Cell Neuroprotection

This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen for potential compounds to protect retinal ganglion cells (RGCs) from responding to increased intraocular pressure (IOP). The modified OHT model may provide an effective and reliable method for screening drugs to protect RGCs from glaucoma.

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Image Analysis in Laser-Induced Choroidal Neovascularization (CNV) Model in Rats

The study was how to more easily analyze images in a laser-induced choroidal neovascularization (CNV) model in rats. The experimental CNV was induced by a laser in rats and confirmed by the results from histopathology, fluorescein angiography and SD-OCT.  The area of retinal leakage was not significantly different between Group 1 (Laser only) and Group […]

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Evaluation of Animal Models for Retinal Degenerative Treatments

Several studies were conducted to create neovascularization animal models in mice and rats. Successful surgical procedures exhibited that the corneal neovascularization in rodents was reproducible and effective.

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