In Vivo Antimicrobial Studies / Animal Models of Infection
Toxikon offers a state-of-the-art animal facility. Animal models of infection are an invaluable resource for translational research and development and offer efficacy data not available through strictly in vitro approaches. Administration of the challenge, site of infection, and microbial challenge vary according to the product and target claims. The methodology involves inoculating model animals with an indicator microorganism(s) or promoting infection from resident microorganisms and applying product or drug regimen. The result of the microbial injury may be characterized directly by visualization with electron microscopy or quantitative recovery. Additionally, injury may be characterized by the histological effects on surrounding tissues or by quantitation of immune response indicators and compared to untreated controls.
Testing Capabilities
- Preservative Effectiveness
- Minimum Inhibitory Concentration
- Zone of Inhibition
- Time Kill
- Anti-Adherence
- Animal Models of Infection
Testing Categories and Specifications
| Test Name | Sample Needed | Turn-Around Time |
|---|---|---|
| Preservative Efficacy – USP | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Zone of Inhibition – USP/AATCC | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Time Kill – ASTM | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Disinfectant Efficacy Testing – AOAC/ASTM/USP | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Minimum Inhibitory Concentration (MIC) | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Minimum Bactericidal Concentration (MBC) | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Fractional Inhibitory Concentration (FIC) | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Anti-Adherence | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Bacterial Anti-Virulence Studies | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |
| Animal Models of Infection | Sample quantity varies per study | Approximate turnaround time is based upon study specific parameters. |